The rise of biologics, gene therapies and time sensitive medicines means that pharmaceutical cold chain companies are more important than ever. Pharmaceutical cold chain companies handle temperature controlled storage, packaging and transport to ensure vaccines, biologics and gene therapies remain safe from manufacture to patient delivery. The global pharmaceutical cold chain logistics market was about masuknya US$18,61 miliar 2024 and is projected to reach US$27.11 billion by 2033 at a compound annual growth rate of 4.3%. Choosing the right partner can seem daunting, but this guide helps you evaluate providers, understand innovations and identify trends shaping the industry in 2025.
Identify key services offered by pharmaceutical cold chain companies, from end to end logistics to specialized packaging, using long tail keywords such as pharma cold chain logistics companies.
Compare leading logistics providers and packaging innovators in 2025, including UPS Healthcare, DHL, Fedex, and Cold Chain Technologies.
Understand cutting edge technology and equipment, such as reusable pallet shippers, cryogenic dewars and fiber based packaging.
Learn how IoT and AI improve cold chain monitoring and reduce product loss, using relevant long tail keywords like cold chain monitoring technology.
Explore sustainability and regulatory trends, with insights on reducing carbon footprints and meeting Good Distribution Practice (PDB) standar.
Find practical tips and a checklist to select the best partner and optimize your cold chain operations.
What services do pharmaceutical cold chain companies provide?
Pharmaceutical cold chain companies ensure medicines stay within strict temperature ranges. They provide integrated solutions that include warehousing, kemasan terisolasi, angkutan, pemantauan dan kepatuhan terhadap peraturan. The core services include:
Penyimpanan yang dikontrol suhu: Warehouses, refrigerated rooms and cryogenic freezers maintain product integrity for drugs requiring +2 ° C ke +8 ° C., –20 °C or cryogenic conditions (–150 °C).
Kemasan terisolasi: Single use and reusable shippers with phase change materials protect shipments and allow last mile delivery even at –70 °C.
Pemantauan waktu nyata: IoT sensors and RFID tags continuously track temperature, kelembaban dan lokasi, providing early alerts to prevent spoilage.
Koordinasi logistik: Perencanaan rute, customs clearance and documentation to ensure timely delivery and minimize delays.
Kepatuhan Pengaturan: Adherence to GDP standards and regional regulations reduces legal risk and guarantees quality.
These services work together like runners in a relay race; each handoff must keep the payload within the required temperature range. Without such coordination, sensitive biologics could lose potency and jeopardize patient safety.
How are biologics changing cold chain demand?
Biologi menjelaskan secara kasar 30% dari semua obat and often require narrow temperature ranges. The COVID 19 pandemic highlighted the need for ultra cold storage, accelerating investment in infrastructure. Tentang 20% Salah satu obat baru yang sedang dikembangkan adalah terapi berbasis gen dan sel memerlukan kontrol suhu yang ketat. Sebagai akibat, pharmaceutical cold chain companies must offer cryogenic storage, specialized packaging and faster transit times.
Which pharmaceutical cold chain companies lead the industry in 2025?
Third party logistics providers and integrators
Perusahaan seperti Layanan Kesehatan UPS, Ilmu Hayati DHL & Healthcare and FedEx dominate the logistics segment by investing heavily in fleet capacity, akuisisi dan platform digital. Their global networks provide end to end transportation and warehousing, including last mile delivery.
| Perusahaan | Layanan inti | Distinguishing features | Manfaat bagi Anda |
| Layanan Kesehatan UPS | Global cold chain transport, warehousing and supply chain integration | Aggressive acquisitions of Frigo Trans and BPL; agreement to acquire Andlauer Healthcare Group for US$1.6 billion; investment of over €20 million in 2024 to double temperature controlled vehicles and expand distribution space to 1.7 juta m² | Broader network with cryogenic capacity; reduced product loss due to integrated monitoring and an expanded fleet |
| Ilmu Hayati DHL & Perawatan kesehatan | Transportasi udara dan darat yang dikontrol suhunya, storage and packaging | Acquired CRYOPDP, a specialty courier handling 600,000 shipments per year in 15 negara. The deal forms a strategic partnership with Cryoport to enhance pharma logistics | Enhanced global coverage and white glove courier expertise for clinical trials, biopharma and cell gene therapies |
| Fedex | Express and Custom Critical services for air and ground cold chain | Expands cold chain capacity with IoT sensors and blockchain traceability | Visibility and security through real time tracking; flexible service levels across modes |
| Logistik CEVA & Kuehne+Nagel | Specialized pharmaceutical logistics, GDP compliant warehouses and last mile delivery | Partner with airlines and biotech firms; develop rental models for reusable packaging. CEVA notes that reusable packaging adoption could double from 30% ke 70% di tahun-tahun mendatang | Collaboration and sustainable packaging options that reduce waste and cost |
| SebaliknyaDingin & Logistik Silsilah | Extensive cold storage networks | Incorporate warehouse robotics and smart software to optimize energy consumption and maintain temperature integrity | Energy efficient operations with scalability across North America and Asia |
| AmerisourceBergen & Kesehatan Kardinal | Pharmaceutical distribution and packaging services | Provide cold chain packaging via subsidiary Sonoco TermoSafe, delivering high volume shipments to hospitals and pharmacies | Reliability and broad distribution channels, including real time monitoring |
Spesialis pengemasan dan peralatan
Packaging innovators design containers that maintain stable temperatures, reduce waste and support reusability. Pemain kuncinya termasuk:
Teknologi Rantai Dingin (CCT) – In April 2025, CCT launched the Elit Menara CCT, a reusable universal pallet shipper unveiled at LogiPharma 2025. The 1600 liter design accommodates both Euro and US pallets and is the lightest solution of its kind. It maintains four temperature ranges (<–60 °C, –20 °C, +5 ° C., +20 ° C.) untuk lebih 120 jam tanpa daya eksternal, uses phase change materials or dry ice and includes an integrated IoT system for real time monitoring.
C Safe Global – Known for active heating and cooling containers, C Safe offers multi use dewars for cell and gene therapies. The dewars use liquid nitrogen dry vapor technology to maintain –150 °C or colder and integrate TracSafe RLT real time tracking devices.
BioTermal Pelikan – Provides reusable Crēdo™ Cube containers and single use CoolPall™ kotak; integrated data loggers track temperature. Its flexible Crēdo™ Go solution adapts to different program needs.
lingkungan hidup – Offers active air cargo containers with compressor driven cooling and battery power to maintain stable temperatures; considered essential for transporting gene therapies at –70 °C.
DS Smith – Introduced TailorTemp®, a fiber based, temperature controlled packaging solution showcased at PharmaPack Europe 2025. Made entirely from corrugated cardboard, TailorTemp is 100% dapat didaur ulang, can be shipped flat to reduce transport costs, and maintains cool temperatures for 36 jam. DS Smith plans to extend cooling to 96 hours as materials improve.
Peralatan KTT, Philipp Kirsch and Binder – Manufacture medical refrigerators, ultra low temperature freezers and climate chambers operating from –40 °C to –90 °C with password protection and alarms.
Azenta & Ilmiah Thermo Fisher – Provide automated storage and cryogenic transport solutions; Thermo Fisher’s subsidiary Aman introduced multi use dewars with real time tracking to transport cell and gene therapies at –150 °C.
Penyedia teknologi dan pemantauan
The cold chain ecosystem also includes providers of digital platforms and sensors. teknologi sensitif diluncurkan TempTale GEO X in February 2024, an IoT temperature monitoring solution tailored for life sciences logistics. TransVoyant Dan Rasa Kargo use AI to predict disruptions and create digital twins. Tag N Trac offers Bluetooth and cellular trackers for real time visibility. These technologies increase transparency and help companies meet stringent GDP requirements.
Bagaimana perusahaan terkemuka membedakannya
The table below summarizes how top providers stand out and how their differentiators translate into practical benefits.
| Perusahaan | Pembeda | Manfaat praktis |
| Layanan Kesehatan UPS | Aggressive acquisition strategy (Trans Dingin, BPL, Andlauer), expanded fleet and facilities | Unparalleled reach, enhanced cryogenic capacity and integrated visibility across the supply chain |
| Ilmu Hayati DHL & Perawatan kesehatan | Acquisition of CRYOPDP, integration with DHL Express and DHL Global Forwarding | White glove courier expertise for clinical trials and cell gene therapies; global network synergy |
| Fedex | Investment in IoT sensors and blockchain for traceability | Real time shipment tracking and secure, tamper evident records |
| Logistik CEVA | Rental model for sustainable packaging; collaboration with drug manufacturers | Cost effective reusable packaging that reduces waste and supports sustainability goals |
| Elit Menara CCT | Ringan 1600 L pallet shipper, four temperature ranges, integrated IoT | Universal compatibility and long hold time without power, reducing operational complexity and waste |
| DS Smith TailorTemp | 100% recyclable fiber based packaging with 36 hour cooling | Sustainable alternative to expanded polystyrene (EPS); flat pack shipping lowers costs and carbon emissions |
How do innovations like IoT and AI transform cold chain operations?
Pemantauan waktu nyata is the backbone of modern cold chain logistics. IoT sensors embedded in packaging and vehicles monitor temperature, kelembaban dan lokasi terus menerus. When linked to cloud platforms, they trigger alerts for deviations, memungkinkan intervensi cepat. Misalnya, Sensitech’s TempTale GEO X provides real time analytics across modes and enhances supply chain efficiency.
Kecerdasan buatan (Ai) Dan analitik prediktif help logistics providers anticipate delays and optimize routes. By creating digital twins of shipments and supply chains, AI models can simulate various scenarios and suggest proactive measures. TransVoyant and CargoSense use AI to predict shipment issues before they occur. UPS and FedEx integrate AI into network planning to reduce dwell times and manage capacity.
Robotics and automation in warehouses improve throughput and consistency. Studies suggest that many warehouses remain unautomated, presenting growth potential. Sistem penyimpanan dan pengambilan otomatis (AS/RS) dan penanganan robotik mengurangi biaya tenaga kerja, minimize errors and improve temperature control. Misalnya, Lineage Logistics integrates warehouse robotics and smart software to maintain energy efficiency.
Blockchain dan ketertelusuran solutions ensure data integrity. FedEx uses blockchain for tamper proof temperature logs, enabling regulators and customers to verify compliance. Blockchain can also streamline customs clearance and reduce paperwork.
What packaging and equipment solutions are available?
Reusable pallet shippers and parcel containers
Reusable pallet shippers like Elit Menara CCT Dan CSafe’s Multi Use Dewars offer extended holding times and integrated monitoring. CCT Tower Elite uses phase change materials or dry ice to maintain temperatures across four ranges and includes an IoT system for near real time tracking. CSafe’s dewars maintain –150 °C using liquid nitrogen and feature real time tracking via TracSafe RLT devices.
Fibre based and recyclable packaging
Keberlanjutan adalah pendorong utama. DS Smith’s TailorTemp packaging is made entirely from corrugated cardboard, adalah 100% recyclable and can be shipped flat, mengurangi biaya transportasi. The design currently maintains cool temperatures for 36 jam, with plans to extend to 96 jam. Ranpak’s RecyCold climaliner and 2nd Level Global Solutions’ Solaris paper based thermal pallet covers provide recyclable alternatives, demonstrating industry wide progress.
Ultra low temperature freezers and cryogenic systems
Peralatan KTT, Philipp Kirsch and Binder manufacture refrigerators and freezers that operate from –40 °C to –90 °C and include password protection and alarm systems. Azenta and Thermo Fisher offer automated storage solutions and cryogenic dewars, ensuring safe transport of cell and gene therapies at –150 °C.
How can you select the right pharmaceutical cold chain partner?
Choosing a partner requires assessing service scope, teknologi, network reach, sustainability practices and regulatory compliance. Use the following checklist to guide your evaluation:
Assess network coverage: Confirm that providers have facilities near your manufacturing sites and customer locations to reduce transit time.
Verify temperature ranges: Ensure the company can handle the specific temperature range your product requires (MISALNYA., +2 ° C ke +8 ° C., –20 °C, kriogenik).
Evaluate monitoring technology: Look for providers using IoT sensors, real time dashboards and predictive analytics. Companies like Sensitech, TransVoyant and CargoSense offer solutions that reduce spoilage.
Check sustainability commitments: Ask about reusable packaging, energi terbarukan, and carbon reduction targets. DS Smith’s TailorTemp and CCT’s Tower Elite illustrate sustainable innovation.
Review certifications and compliance: Confirm adherence to GDP, ISO standards and local regulations. Verify that employees receive regular training and that facilities undergo periodic audits.
Compare cost structures: Evaluate pricing models, including rental options for reusable containers. Consider total cost of ownership, including return logistics for reusable packaging.
Ask for performance metrics: Request data on on time deliveries, kunjungan suhu, and spoilage rates. High on time performance and low excursion rates indicate reliability.
Tip dan rekomendasi praktis
For clinical trials: Choose a partner experienced in managing investigational medicinal products. White glove couriers like CRYOPDP (now part of DHL) specialize in clinical trial logistics.
Untuk terapi sel dan gen: Require ultra cold conditions; look for providers offering cryogenic dewars (C Safe, Termo Fisher) and active containers (lingkungan hidup).
Untuk vaksin dan biologi: Use providers with robust last mile networks and sustainable packaging, such as UPS Healthcare, DHL and CEVA Logistics. Consider fiber based packaging like DS Smith’s TailorTemp.
Untuk usaha kecil: Consider partnering with third party logistics providers that offer scalable solutions and access to cutting edge technology without large capital investment.
Studi kasus: Di awal 2025, UPS Healthcare finalized its acquisition of German cold chain specialists Frigo Trans dan BPL, enhancing its European network. The acquisition provided cryogenic transport capabilities ranging from –196 °C to +25 °C and integrated Pan European cold chain transportation. This expansion means pharmaceutical clients in Europe can ship gene therapies and biologics without switching providers mid journey, ensuring product integrity and reducing risk.
What are the latest trends and developments in 2025?
Keberlanjutan dan kemasan melingkar
The cold chain industry contributes around 4% emisi gas rumah kaca global, prompting regulators and customers to demand more sustainable practices. Inovasi meliputi:
Kemasan berbasis serat: DS Smith’s TailorTemp demonstrates how recyclable materials can replace expanded polystyrene, providing 36 hour thermal stability and plans for 96 jam.
Adopsi kemasan yang dapat digunakan kembali: CEVA Logistics notes that utilization rates of reusable temperature controlled packaging could rise from 30% ke 70%, driven by rental models and collaboration.
Renewable energy and alternative fuels: DHL is focusing on sustainable packaging and alternative fuels across its network. UPS invests in energy efficient vehicles and warehouses.
Carbon accounting tools: Many providers now offer dashboards that calculate carbon emissions per shipment, helping clients meet ESG targets.
Technology and digital transformation
Real time monitoring and predictive analytics continue to grow. TempTale GEO X and AI driven platforms like TransVoyant reduce spoilage and improve planning.
Otomasi dan robotika are being deployed in cold warehouses. While around 80% gudang tetap tidak terotomatisasi, innovations such as automated storage and retrieval systems and robotic palletizers are gaining traction.
Blockchain untuk ketertelusuran ensures tamper proof records and supports regulatory compliance.
Market growth and M&A
The pharmaceutical cold chain market is set to grow from masuknya US$18,61 miliar 2024 menjadi US$27,11 miliar pada 2033. Demand is fueled by the increasing share of biologics and gene therapies, requiring specialized logistics.
Merger dan akuisisi continue: UPS acquired Frigo Trans and BPL and agreed to buy Andlauer Healthcare Group, while DHL acquired CRYOPDP. These deals expand networks and deepen capabilities.
Regulatory tightening and quality standards
Regulatory bodies tighten enforcement of Good Distribution Practice (PDB). Companies must demonstrate validated processes, dokumentasi dan pelatihan. Real time monitoring and digital quality management systems are increasingly necessary to meet auditors’ expectations.
Pertanyaan yang sering diajukan
Q1: What makes pharmaceutical cold chain companies different from standard logistics providers?
Cold chain companies specialize in maintaining narrow temperature ranges, using insulated packaging, kendaraan berpendingin, IoT monitoring and compliance protocols. Standard logistics often lack these specialized systems.
Q2: How do reusable pallet shippers reduce costs?
Reusable pallet shippers like CCT Tower Elite or CSafe dewars can be rented. Although initial rental costs may be higher than single use packaging, reusability reduces waste and total cost of ownership.
Q3: Are fiber based cold chain packages as reliable as EPS?
DS Smith’s TailorTemp packaging has proven to maintain temperatures for 36 hours and is made from 100% recyclable corrugated cardboard. The company aims to extend this to 96 jam, showing strong reliability and sustainability.
Q4: Which providers offer cryogenic transport for gene therapies?
Envirotainer supplies active air cargo containers with compressor driven cooling and battery power, enabling –70 °C transport. CSafe’s Multi Use Dewars maintain –150 °C using liquid nitrogen.
Q5: What should I look for when evaluating monitoring technology?
Ensure sensors provide continuous temperature and location data, terintegrasi dengan dashboard, and support predictive analytics. Real time alerts and compliance reporting are key features.
Q6: How will automation impact cold chain logistics?
Automation will improve accuracy, reduce labor costs and enhance energy efficiency. Dengan 80% of warehouses still not automated, the adoption of robotics and automated storage systems is expected to accelerate by 2028.
Q7: How can I reduce the environmental impact of my cold chain operations?
Use reusable packaging, choose providers that invest in renewable energy and electric vehicles, and consider fiber based solutions. Calculate and track carbon emissions per shipment to make data driven decisions.
Ringkasan dan Rekomendasi
The pharmaceutical cold chain industry is evolving rapidly. Tren utama untuk 2025 include sustainability, pemantauan waktu nyata, kemasan yang dapat digunakan kembali, and consolidation through acquisitions. Leading logistics providers like Layanan Kesehatan UPS, Ilmu Hayati DHL & Perawatan kesehatan, Fedex, CEVA Dan Kuehne+Nagel are expanding their networks and investing in technology to meet the growing demand for biologics and cell gene therapies. Packaging innovators such as Teknologi Rantai Dingin, C Safe Global Dan DS Smith offer reusable and recyclable solutions that extend temperature stability and reduce waste. To choose the right partner, assess network reach, teknologi, sustainability practices and compliance. Use reusable packaging, leverage IoT monitoring and adopt AI to optimize operations. Remember that sustainable practices not only reduce emissions but also lower costs and enhance brand reputation.
Langkah selanjutnya yang dapat ditindaklanjuti
Audit your current cold chain process: Identify gaps in storage, kemasan, transit and monitoring. Evaluate temperature excursion rates and spoilage incidents.
Define your temperature requirements: Match your product’s stability profile to providers’ capabilities (+2 ° C ke +8 ° C., –20 °C or cryogenic).
Shortlist providers: Compare logistics integrators and packaging specialists based on network coverage, service scope, sustainability commitments and technology offerings.
Request proposals and pilot runs: Ask shortlisted companies for performance metrics, and conduct pilot shipments to validate temperature stability and service quality.
Negotiate contracts with flexibility: Choose rental options for reusable packaging and ensure service level agreements include penalties for temperature excursions.
Implement continuous improvement: Collect data from IoT sensors, analyze trends and work with partners to address bottlenecks. Review performance quarterly and adjust strategies.
Tentang tempk
Pada Tempk, we develop innovative cold chain packaging solutions for pharmaceuticals, makanan dan produk sensitif suhu lainnya. Our products range from reusable insulated boxes and bags ke Gel Ice Packs, bahan perubahan fase Dan electric cooler bags. We invest in R&D to create eco friendly, recyclable materials and offer customized packaging tailored to your payload and temperature requirements. We guarantee product safety through strict quality control, validated thermal performance and compliance with GDP standards. With a focus on sustainability and customer satisfaction, we help you simplify your cold chain operations and protect your valuable cargo.
Panggilan untuk bertindak
Ready to secure your biologics with reliable cold chain packaging? Hubungi Tempk today to discuss your specific needs and discover how our reusable solutions can reduce costs and environmental impact. Our experts will help you design a tailored packaging strategy that ensures product integrity from factory to patient.
